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New
Congenital Hypothyroidism Screening Information
In response to recent budget
reductions, Arizona’s Newborn Screening (NBS) Program will shortly be
changing our laboratory method for the detection of Congenital
Hypothyroidism (CH) in newborns by bloodspot. Effective May 1, 2009,
screening results will be reported to you for thyroid stimulating hormone (TSH)
only instead of thyroxine (T4) with a TSH backup. This decision was arrived
at with the advice and agreement of our consulting pediatric
endocrinologists and we believe that this new method will improve the
accuracy and reliability of the determination of CH in newborns while
significantly reducing analytical costs and false positives.
There are two widely used screening strategies for the detection of
congenital hypothyroidism: a primary TSH/backup T4 method and a primary
T4/backup TSH method. Since the diagnosis of primary hypothyroidism requires
an elevated TSH, most programs in Europe, Japan, Canada, Mexico, and the
United States screen by using primary TSH measurements. It should be noted
that programs that use TSH only do not detect infants with low levels of T4
related to prematurity or TBG deficiency, neither of which require
treatment, nor do they detect secondary (pituitary) or tertiary
(hypothalamic) forms of hypothyroidism. The latter, whose incidence is
estimated at 1:100,000 compared to 1:2000 – 1:4000 for primary congenital
hypothyroidism, are often accompanied by other findings (e.g. hypoglycemia,
mid-line defects, etc.).1
We will continue to communicate with you as we make changes to our testing
and follow-up protocols for the other inherited disorders screened by our
program. If you have any questions related to this laboratory change, please
do not hesitate to contact either Dr. Sundin Applegate, NBS Medical
Director, at applegs@azdhs.gov or
(602) 542-1223 or Ward Jacox, NBS Office Chief at
jacoxw@azdhs.gov or (602) 364-1410.
If you have clinical questions, please contact one the consulting pediatric endocrinologists listed below.
Dr. Ed Holland |
East Valley Pediatric Endocrinology |
480-464-8600 |
Dr. Roger Johnsonbaugh |
Az. Pediatric Endocrinology |
602-274-5078 |
Dr. Mark Wheeler |
University Physicians |
520-626-6077 |
Dr. Khalid Hasan |
Phoenix Children’s Hospital |
602-546-0935 |
Dr. Donnie Wilson |
Phoenix Children’s Hospital |
602-546-0935 |
Dr. Alvin Perelman |
Southwest Pediatric Endocrinology |
480-323-4800 |
1
Update of Newborn Screening and Therapy for Congenital Hypothyroidism.
American Academy of Pediatrics, Susan R. Rose, and the Section on
Endocrinology and Committee on Genetics, American Thyroid Association,
Rosalind S. Brown, and the Public Health Committee and Lawson Wilkins
Pediatric Endocrine Society PEDIATRICS Volume 117, Number 6, June 2006
Blood Specimens
Order our
brochures
[PDF 24K]
for hospitals and providers.
Order blood specimen collection kits
[PDF
8K]
for hospitals and providers.
View a presentation about proper
collection [PDF601K]
Print a poster describing proper
collection [PDF 372K]
Print a poster describing common collection mistakes [PDF 212K]
Disorder
Act Sheets (What to Do)
Human Genetics and Medical Research Information about understanding
genetic diseases, DNA, genes, and chromosomes.
Mountain
States Genetics Regional Collaborative Center Also includes additional links
to parent resources. Also includes additional links to parent resources.
Sickle Cell Trait: Answers to Commonly Asked Questions
[PDF 64K]
Parent Refusal
Form
[PDF16K]
Cystic
Fibrosis Screening Process with Mutations [PDF 24K]
Hearing
A Family's Checklist:
Infant Hearing (English/Spanish) [PDF 60K]
Family Checklist for Babies at
High Risk for Hearing Loss [PDF 44K]
Top 10 Strategies to Minimize Loss to Follow-up [PDF 172K]
Joint Commission on Infant Hearing (JCIH) 2007 Position Statement
[PDF
756K]
View the Administrative Code (aka Rules) for hearing screening
web
site
Statewide Testing
Contacts
[PDF 552K]
AAP Medical Home
Guidelines
[PDF 891K]
View Larger Map
Screening
and Diagnostic Resources [PDF 520K]
Map of Screening & Diagnostic Resources
[PDF 700K]
National Center for Hearing
Assessment and Management (NCHAM)
Hospital Guidelines
[PDF148K]
History of Arizona Hearing Screening [PDF 600K]
Arizona Hands & Voices brochure: parent support group [PDF 1.24K]
Explanation of Hearing Test: Arabic, Chinese, French, Hindi, Japanese, Korean, Portuguese, Russian, Somali, Spanish, Ukrainian, Vietnamese
Explanation of Hearing Loss: Chinese, French, Hindi, Japanese, Korean, Russian, Somali,
Spanish, Ukrainian
CDC
Early
Hearing Detection and Intervention (EHDI)
Hear and Now
My Baby's Hearing - Boy's Town
National Research Hospital
American Academy of Pediatrics (AAP) Newborn
and Infant Hearing Screening Activities
The EAR Foundation
of Arizona
Hear for Kids: loaned hearing aids [PDF 96K]
Newborn Screening
Program Publications:
Newborn Screening: A guide
for parents (English/Spanish) [PDF 168K]
Arizona Hospitals Newborn Hearing Screening Guidelines [PDF
194K]
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